The 2016 Oklahoma Sooners football team represented the University of Oklahoma in the 2016 NCAA Division I FBS football season, the 122nd season of Sooner football. The team was led by two-time Walter Camp Coach of the Year Award winner, Bob Stoops, in his 18th season as head coach. They played their home games at Gaylord Family Oklahoma Memorial Stadium in Norman, Oklahoma. They are a charter member of the Big 12 Conference.
Conference play began against TCU on October 1 in Fort Worth, Texas and ended in the annual Bedlam Game against Oklahoma State on December 3 in Norman.